In human specimens, CRC patients exhibiting an active CRCSC signal (Snail<sup>+</sup>IL8<sup>+</sup>) showed elevated tumor infiltration of MPO<sup>+</sup> neutrophils, and high (in the top 10%) MPO expression predicted poor survival of CRC patients.
Taken together, our findings indicate that <i>MPO</i> SNP rs2333227 serves as a marker of enhanced risk for development of colorectal cancer.<b>Significance:</b> MPO polymorphisms are a guide for high risk and poor prognosis in patients colorectal cancer.<i></i>.
The epigenetic/genetic associations related to elevated MPO staining in UC-CRC may offer new methods for risk stratification and adjunctive screening tools.